Emma Kimilainen has been ruled out of this weekend's W Series round at Misano on medical grounds.
The Finnish driver has been advised by the series' contracted health and wellbeing experts, not to drive this weekend in Italy.
The grid will however still feature 19 drivers with reserves Sarah Bovy and Vivien Keszthelyi stepping up.
"I’m very disappointed not to be able to race at Misano this weekend, but I understand the advice I’ve been given and I’ll abide by it," said Kimilainen.
"I feel I’ve been on top of the W Series car in the practice sessions and qualifying sessions I completed at Hockenheim and Zolder, and it’s obviously a great pity that, through no fault of my own, I didn’t get a chance to translate that pace into race results.
"But my hope is now to be fully fit for Norisring in early July, so that I can finish the W Series season with three strong performances at Norisring, at Assen and at Brands Hatch."
Dave Ryan, W Series Racing Director, added: "We’re disappointed for Emma, who has been competent and quick whenever she’s driven the W Series car, but of course we look forward to welcoming her back as and when she’s fit enough to compete again.
“In the meantime, we’re happy to be able to offer the opportunity to race at Misano to both Sarah [Bovy] and Vivien [Keszthelyi], our two reserve drivers.
“Sarah and Vivien were both entered for the W Series race at Zolder last month, albeit at the eleventh hour, but Sarah didn’t even get to start and Vivien was involved in a collision with another competitor. Therefore, it’s a positive development for them both, and indeed for all of us, that they’ll travel to Misano with the foreknowledge that they’ll be competing in both practice sessions, in qualifying and in the race.
“We hope they’ll both work hard with their engineers, will duly perform well, and will therefore be able to record good results come Saturday afternoon.”