Ayrton Senna's winning McLaren MP4/8 chassis will go up for auction in May and is expected to fetch more than $5 million (£3.5m).
The chassis, which Senna drove to victory three times in 1993, including his final Monaco win before it was replaced with 'chassis seven' in Portugal, will be auctioned off by Bonhams.
Bonhams have described the MP4/8 as being "startlingly well-preserved" and its Ford engine in "running order".
"Ayrton Senna was the most charismatic grand prix car driver of the modern era, and the MP4/8A was the car with which his team, McLaren, surpassed Ferrari as the most successful team in Formula 1 world championship history," said Mark Osborne, Bonhams' specialist global head of motorsport.
"This particular chassis, number six, cemented Senna's legend as The Master of Monaco. We at Bonhams are both honoured and thrilled to be presenting one of the most significant grand prix cars of all time."
The auction will have some way to go if it's to beat the record set by Michael Schumacher's 2001 Ferrari, which sold for $7.5million (£5.3m) in November, making it the most valuable modern era F1 car to be sold at auction.
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