Nico Rosberg turned the tables on Mercedes team-mate Lewis Hamilton, topping the session by almost half a second, switching positions compared to FP1 which saw the Briton leading by a similar gap.
The Mercedes pair were well ahead of nearest rival Ferrari however, as Sebastian Vettel could only get within 0.960 seconds of the Mercedes, whilst Kimi Raikkonen was a further two-tenths off.
Daniel Ricciardo was fifth ahead of Valtteri Bottas who was sixth quickest after a spin at Pinheinho.
Meanwhile the red flags came out for Fernando Alonso. The Spaniard’s Honda engine blew up with a puff of smoke, whilst the team warned Jenson Button of the issue.
2015 Brazilian Grand Prix Practice Times (FP2):
| # | Driver | Team | Best lap | Gap | Laps |
| 01 | Nico Rosberg | Mercedes | 1:12.385 | 42 | |
| 02 | Lewis Hamilton | Mercedes | 1:12.843 | 0.458 | 39 |
| 03 | Sebastian Vettel | Ferrari | 1:13.345 | 0.960 | 41 |
| 04 | Kimi Raikkonen | Ferrari | 1:13.500 | 1.115 | 43 |
| 05 | Daniel Ricciardo | Red Bull | 1:13.585 | 1.200 | 39 |
| 06 | Valtteri Bottas | Williams | 1:13.603 | 1.218 | 37 |
| 07 | Romain Grosjean | Lotus | 1:13.634 | 1.249 | 45 |
| 08 | Nico Hulkenberg | Force India | 1:13.710 | 1.325 | 43 |
| 09 | Daniil Kvyat | Red Bull | 1:13.848 | 1.463 | 40 |
| 10 | Felipe Massa | Williams | 1:13.870 | 1.485 | 42 |
| 11 | Sergio Perez | Force India | 1:14.056 | 1.671 | 34 |
| 12 | Pastor Maldonado | Lotus | 1:14.124 | 1.739 | 42 |
| 13 | Felipe Nasr | Sauber | 1:14.134 | 1.749 | 44 |
| 14 | Max Verstappen | Toro Rosso | 1:14.226 | 1.841 | 35 |
| 15 | Carlos Sainz Jnr | Toro Rosso | 1:14.326 | 1.941 | 45 |
| 16 | Jenson Button | McLaren | 1:14.644 | 2.259 | 37 |
| 17 | Marcus Ericsson | Sauber | 1:14.772 | 2.387 | 38 |
| 18 | Fernando Alonso | McLaren | 1:15.129 | 2.744 | 10 |
| 19 | Will Stevens | Marussia | 1:16.501 | 4.116 | 35 |
| 20 | Alexander Rossi | Marussia | 1:16.787 | 4.402 | 35 |
