| # | Rider | Bike | Points | |
|---|---|---|---|---|
 | Francesco Bagnaia | Ducati | 265 | |
 | Fabio Quartararo | Yamaha | 248 | |
| Enea Bastianini | Ducati | 219 | |
 | Aleix Espargaro | Aprilia | 212 | |
 | Jack Miller | Ducati | 189 | |
 | Brad Binder | KTM | 188 | |
| Alex Rins | Suzuki | 173 | |
| Johann Zarco | Ducati | 166 | |
| Jorge Martin | Ducati | 152 | |
 | Miguel Oliveira | KTM | 149 | |
| Maverick Vinales | Aprilia | 122 | |
| Luca Marini | Ducati | 120 | |
| Marc Marquez | Honda | 113 | |
| Marco Bezzecchi | Ducati | 111 | |
| Joan Mir | Suzuki | 87 | |
| Pol Espargaro | Honda | 56 | |
| Alex Marquez | Honda | 50 | |
 | Takaaki Nakagami | Honda | 48 | |
| Franco Morbidelli | Yamaha | 42 | |
| Fabio Di Giannantonio | Ducati | 24 | |
| Andrea Dovizioso | Yamaha | 15 | |
| Raul Fernandez | KTM | 14 | |
| Darryn Binder | Yamaha | 12 | |
| Remy Gardner | KTM | 10 |
2022 MotoGP Standings
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