| Team | Bike | Riders | Rider No. | Nationality |
|---|---|---|---|---|
| Aprilia Racing Team Gresini | Aprilia | Lorenzo Savadori Aleix Espargaro | 32 41 | Italian  Spanish  |
| Ducati Team | Ducati | Jack Miller Francesco Bagnaia | 43 63 | Australian  Italian |
| Esponsorama Racing | Ducati | Luca Marini Enea Bastianini | 10 23 | Italian Italian |
| LCR Honda | Honda | Takaaki Nakagami Alex Marquez | 30 73 | Japanese  Spanish |
| Monster Energy Yamaha MotoGP | Yamaha | Maverick Vinales Fabio Quartararo | 12 20 | Spanish German  |
| Petronas Yamaha SRT | Yamaha | Franco Morbidelli Valentino Rossi | 21 46 | Italian Italian |
| Pramac Racing | Ducati | Johann Zarco Jorge Martin | 5 89 | French  Spanish |
| Red Bull KTM Factory Racing | KTM | Brad Binder Miguel Oliveira | 33 88 | Finnish  Italian  |
| Red Bull KTM Tech 3 | KTM | Danilo Petrucci Iker Lecuona | 9 27 | Italian Spanish |
| Repsol Honda Team | Honda | Pol Espargaro Marc Marquez | 44 93 | Spanish Spanish |
| Team Suzuki Ecstar | Suzuki | Joan Mir Alex Rins | 36 42 | Spanish Spanish |
2021 MotoGP Team/Rider Line-Up
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